Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity
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منابع مشابه
Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity.
The novel photoactive ruthenium(ii) complex cis-[Ru(bpy)2(INH)2][PF6]2 (1·2PF6, INH = isoniazid) was designed to incorporate the anti-tuberculosis drug, isoniazid, that could be released from the Ru(ii) cage by photoactivation with visible light. In aqueous solution, 1 rapidly released two equivalents of isoniazid and formed the photoproduct cis-[Ru(bpy)2(H2O)2]2+ upon irradiation with 465 nm b...
متن کاملCombatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity† †Electronic supplementary information (ESI) available: Experimental details include materials, instrumentation, synthesis and characterization, photoactivity against bacteria, transient electronic absorption spectroscopy and computational analysis. Table S1–S5 show the data of X-ray structures and DFT analysis, Fig. S1–S12 give X-ray crystal structures and dark stability of the compound, the extinction coefficients for cis-[Ru(bpy)2(INH)2]2+, HR-MS peaks for the photoproduct, the stability of the photoproduct, 1H NMR spectrum and HPLC analysis upon photoirradiation, photoactivity against bacteria and the pictures of DFT analysis. CCDC 1474453. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc03028a Click here for additional data file. Click here for additional data file.
Combatting AMR: Photoactivatable Ruthenium(II)isoniazid Complex Exhibits Rapid Selective Antimycobacterial Activity† Nichola A. Smith, Pingyu Zhang, Simon E. Greenough, Michael D. Horbury, Guy Clarkson, a Daniel McFeely, Abraha Habtemariam, Luca Salassa, Vasilios G. Stavros, Christopher Dowson,* Peter J. Sadler* Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2017
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c6sc03028a